There are 346 schools in 32 Division I basketball conferences. Each conference, except for the newly formed Great West Conference, receives an automatic bid to the NCAA Men's Division I Basketball Championship. The conferences are as follows:

There are also 4 independent Division I schools without conference affiliation, for the 2010-11 season.

There are 22 Division II basketball conferences. The conferences are as follows:

There are also 22 independent Division II schools without conference affiliation, for the 2010-11 season.

In past decades, the NBA held to tradition and drafted players who had graduated from college. This was a mutually beneficial relationship for the NBA and colleges—the colleges held onto players who would otherwise go professional, and the NBA did not have to fund a minor league. As the college game became commercialized, though, it became increasingly difficult for "student athletes" to be students. Specifically, a growing number of poor, under-educated, highly talented teenage basketball players found the system exploitative—they brought in funds to schools where they learned little and played without income.

The American Basketball Association began to employ players who had not yet graduated. After a season of junior college, a season at the University of Detroit, and an Olympic gold medal, Spencer Haywood played the 1969-70 season with the ABA's Denver Rockets. He signed with the NBA's Seattle SuperSonics in 1970, before his college class graduation, defying NBA rules. Haywood pleaded that, as his family's sole wage earner, he should be allowed to earn a living in the NBA or else his family would face destitution. The ensuing legal battle went to the U.S. Supreme Court which ruled in 1971 that the NBA does not have the same antitrust exemption enjoyed by Major League Baseball. Thereafter, collegiate players demonstrating economic hardship were allowed early entry into the NBA Draft. The hardship requirement was eliminated in 1976.

In 1974, Moses Malone joined the Utah Stars of the American Basketball Association (which became part of the NBA after the ABA-NBA merger in 1976) straight out of high school and went on to a Hall of Fame career. The past 30 years have seen a remarkable change in the college game. The best international players routinely skip college entirely, many American stars skip college (Shawn Kemp, Kevin Garnett, Kobe Bryant, Tracy McGrady, Dwight Howard, Amar'e Stoudemire and LeBron James) or only play one year (Carmelo Anthony, Chris Bosh, Kevin Durant, Greg Oden) and only a dozen or so college graduates are now among the 60 players selected in the annual NBA Draft. Fewer high schoolers will progress directly to the NBA without at least one year of college basketball beginning in 2006; citing maturity concerns after several incidents involving young players, the labor agreement between players and owners now specifies that players must turn 19 years of age during the calendar year of the draft to be eligible. Additionally, U.S. players must be at least one year removed from their high school graduation.

The pervasiveness of college basketball throughout the nation, the large population of graduates from "major conference" universities, and the NCAA's marketing of "March Madness" (officially the NCAA Men's Division I Basketball Championship), have kept the college game alive and well. Some commentators have argued that the higher turnover of players has increased the importance of good coaches. Many teams have been highly successful, for instance, by emphasizing personality in their recruiting efforts, with the goal of creating a cohesive group that, while lacking stars, plays together for all 4 years and thus develops a higher level of sophistication than less stable teams could achieve.

The NCAA Men's Basketball Rules Committee, consisting of coaches from all three divisions of the NCAA, sets the rules for college men's basketball play. A parallel committee sets rules for college women's play. Although many of the NBA and WNBA rules apply in NCAA play, there are differences that make NCAA play unique.

An NCAA game is divided into two halves, each 20 minutes long, while NBA games are played in four quarters of 12 minutes each and WNBA games are played in 10-minute quarters. The NCAA shot clock gives a men's team 35 seconds to shoot and a women's team 30 seconds, while the shot clock used in both the NBA and WNBA gives teams 24 seconds. Also, NCAA men's teams are allowed 10 seconds to move the ball past the halfcourt line, and NCAA women's teams have no time limit on moving the ball past the halfcourt line, while NBA and WNBA rules allow only 8 seconds. However, like the NBA and WNBA (and high school basketball), during the last minute of each half, the game clock keeps time remaining in the period measured in tenths of a second, rather than full seconds.